prasterone

General

Pronunciation:
pras-ter-one

Trade Name(s)

  • Intrarosa

Ther. Class.
none assigned

Pharm. Class.
temporary class steroids

Indications

Moderate to severe dyspareunia.

Action

Inactive steroid that is converted into active androgens and/or estrogens. Exact mechanism in treatment of vulvar and vaginal atrophy in menopausal women not fully established.

Therapeutic Effect(s):

Reduced severity of dyspareunia.

Pharmacokinetics

Absorption: Unknown.

Distribution: Unknown.

Metabolism and Excretion: Metabolized via dehydrogenase, reductase, and aromatase to estradiol and testosterone.

Half-life: Unknown.

TIME/ACTION PROFILE (improvement in dyspareunia severity)

ROUTEONSETPEAKDURATION
Vagunknown12 wkunknown

Contraindication/Precautions

Contraindicated in:

  • Undiagnosed abnormal genital bleeding;
  • Current or history of breast cancer;
  • OB: Lactation: Pedi: Only indicated in postmenopausal women

Use Cautiously in:

None noted.

Adverse Reactions/Side Effects

GU: vaginal discharge

* CAPITALS indicate life-threatening.
Underline indicate most frequent.

Interactions

Drug-Drug

None noted.

Route/Dosage

Vag (Adults) Insert one vaginal insert at bedtime.

Availability

Vaginal insert: 6.5 mg

Assessment

  • Assess for pain during intercourse periodically during therapy.

Potential Diagnoses

Implementation

  • Vag Insert vaginal insert at bedtime using applicator provided. Vaginal inserts can be stored at room temperature or refrigerated.

Patient/Family Teaching

  • Explain purpose of prasterone to patient. Instruct patient to read Instructions for Use before inserting prasterone.
  • Inform patient that vaginal discharge and abnormal PAP smear findings may occur with prasterone.
  • Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications during therapy.

Evaluation/Desired Outcomes

Decreased pain during intercourse.

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