Trade Name(s)

  • Skyrizi

Ther. Class.


Pharm. Class.

interleukin antagonists

monoclonal antibodies


Moderate-to-severe plaque psoriasis in patients who are candidates for phototherapy or systemic therapy.


Binds to the p19 protein subunit of the interleukin (IL)-23 cytokine to prevent its interaction with the IL-23 receptor. This cytokine is normally involved in inflammatory and immune responses. Binding to interleukins antagonizes their effects, inhibiting the release of proinflammatory cytokines and chemokines.

Therapeutic Effect(s):

Decrease in area and severity of psoriatic lesions.


Absorption: 89% absorbed following subcutaneous administration.

Distribution: Well distributed to tissues.

Metabolism and Excretion: Broken down by catabolic processes into peptides and amino acids.

Half-life: 28 days.

TIME/ACTION PROFILE (plasma concentrations)

Subcutunknown3–14 days12 wk


Contraindicated in:

  • Hypersensitivity;
  • Active, untreated infection.

Use Cautiously in:

  • History of tuberculosis (possibility of reactivation);
  • OB:  Use during pregnancy only if potential maternal benefit justifies potential fetal risk;
  • Lactation: Safety not established in breast feeding;
  • Pedi:   Safety and effectiveness not established in children.

Exercise Extreme Caution in:

Chronic infection or history of recurrent infection.

Adverse Reactions/Side Effects

Local: injection site reactions

Neuro: headache

Misc: infection, fatigue

* CAPITALS indicate life-threatening.
Underline indicate most frequent.



May ↓ antibody response to and ↑ risk of adverse reactions from  live vaccines ; avoid use during therapy.


Subcut (Adults): 150 mg initially and 4 wk later, then 150 mg every 12 wk.


Solution for injection (prefilled pens): 150 mg/mL

Solution for injection (prefilled syringes): 75 mg/0.83 mL, 150 mg/mL


  • Assess patient for tuberculosis (TB) before starting, during, and after therapy. Do not administer risankizumab to patient with active TB. Consider anti-TB therapy before starting therapy in patients with a past history of latent or active TB in whom an adequate course of treatment cannot be confirmed.
  • Assess skin lesions before and periodically during therapy.
  • Monitor for signs and symptoms of infection (fever, chills, cough, dyspnea, skin infections) periodically during therapy.


  • Complete all age-appropriate vaccinations as recommended by current immunization guidelines before starting therapy.
  • Before injecting, remove carton from refrigerator and without removing prefilled pen or prefilled syringe(s) from the carton, allow risankizumab to reach room temperature out of direct sunlight: 30–90 min for prefilled pen and 15–30 min for the prefilled syringe(s). Solution is colorless to slightly yellow and clear to slightly opalescent; may contain a few translucent to white particles. Do not use if solution is cloudy, discolored, or contains large particles. Do not freeze or shake.
  • Subcut Inject into abdomen or thigh; may inject in upper, outer arm if administered by health care professional or caregiver. Do not inject into areas where skin is tender, bruised, erythematous, indurated or affected by psoriasis. If using 75 mg/0.83 mL syringes, 150 mg dose requires two syringes. Inject in different locations.

Patient/Family Teaching

  • Instruct patient caregiver in correct injection technique and disposal of equipment. Administer at Week 0, Week 4, and every 12 wk thereafter. If a dose is missed, administer as soon as possible, then resume dosing at the regular scheduled time.
  • Advise patient to notify health care professional if signs and symptoms of infection (fever, sweats, chills, cough, shortness of breath, blood in mucus [phlegm], muscle aches, warm, red, or painful skin or sores different from psoriasis, weight loss, diarrhea or stomach pain, burning on urination, urinating more often than usual) occur.
  • Advise patient to avoid live vaccines during therapy.
  • Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other Rx, OTC, or herbal products.
  • Rep:  Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breast feeding. Inform patient of pregnancy exposure registry that monitors outcomes in women with plaque psoriasis who become pregnant while treated with risankizumab. Encourage patient to enroll by calling 1­877-302-2161.

Evaluation/Desired Outcomes

Decrease in area and severity of psoriatic lesions.