d-Xylose Tolerance Test
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General
Synonym/Acronym:
N/A
Common Use:
To assist in the differential diagnosis of small intestine malabsorption syndromes such as celiac, tropical sprue, and Crohn’s diseases.
Specimen:
Plasma collected in a gray-top (fluoride/oxalate) tube and urine (from a 5-hr collection) in a clean amber plastic container.
Normal Findings:
(Method: Spectrophotometry)
| Dose Given | Conventional Units | SI Units (Conventional Units × 0.0666) |
|---|---|---|
| Plasma | ||
| Infant dose 0.5 g/kg (max. 25 g) | Greater than 15 mg/dL after 2 hr | Greater than 1 mmol/L |
| Pediatric dose 0.5 g/kg (max. 25 g) | Greater than 20 mg/dL after 2 hr | Greater than 1.3 mmol/L |
| Adult dose | ||
| 25 g | Greater than 25 mg/dL after 2 hr | Greater than 1.7 mmol/L |
| 5 g (given if patient is known or expected to have severe symptoms) | Greater than 20 mg/dL after 2 hr | Greater than 1.3 mmol/L |
| Urine | |
| Children | Greater than 16%–40% of dose in 5-hr urine sample |
| Adults | Greater than 16% or greater than 4 g of dose in 5-hr urine sample |
| Older adults (65 yr and older) | Greater than 14% or greater than 3.5 g of dose in 5-hr urine sample |
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