Plasminogen and Tissue Plasminogen Activator Antigen



Profibrinolysin, PMG, tissue plasminogen activator antigen, tPA antigen.


To assess thrombolytic disorders such as rapidly developing disseminated intravascular coagulation (DIC), assess thrombotic or slowly developing DIC, and monitor thrombolytic therapy.

Patient Preparation

There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings

Method: Chromogenic for plasminogen activity and enzyme-linked immunosorbent for plasminogen activator antigen.

Plasminogen activity70%–150% of normal
Plasminogen (tPA) antigenLess than 15 ng/mL
Plasminogen activity in newborns is half of adult ranges.

Critical Findings and Potential Interventions


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