Metanephrines, Blood and Urine
To assist in the diagnosis of cancer of the adrenal medulla (e.g., catecholamine-secreting tumors, such as pheochromocytoma [a benign tumor of the adrenal gland] and neuroblastoma [a rare tumor that most often originates in the nervous tissue of the adrenal medulla]) or to assess for the cause of hypertension.
There are no food, fluid, or medication restrictions unless by medical direction. Patients should have their blood drawn for plasma-free metanephrines, while in a supine position. Instruct the patient to avoid excessive exercise and stress during the 24-hr collection of urine. Usually a 24-hr urine collection may be ordered. As appropriate, provide the required urine collection container and specimen collection instructions.
Method: Liquid chromatography Tandem Mass Spectrometry.
|Metanephrines||Less than 0.5 nmol/L|
|Normetanephrines||Less than 0.9 nmol/L|
|Note: Values should be compared to reference intervals determined from the same collection position.|
|Metanephrines, Fractionated (normal BP)||Conventional Units||SI Units (Conventional Units × 5.2)||Conventional Units||SI Units (Conventional Units × 5.2)|
|3–8 yr||29–92 mcg/24 hr||151–478 micromol/day||18–144 mcg/24 hr||94–749 micromol/day|
|9–12 yr||59–188 mcg/24 hr||307–978 micromol/day||43–122 mcg/24 hr||224–634 micromol/day|
|13–17 yr||69–221 mcg/24 hr||359–1149 micromol/day||33–185 mcg/24 hr||172–962 micromol/day|
|18 yr and older||44–261 mcg/24 hr||229–1357 micromol/day||30–180 mcg/24 hr||156–936 micromol/day|
|Normetanephrines, Fractionated (normal BP)||Conventional Units||SI Units (Conventional Units × 5.5)||Conventional Units||SI Units (Conventional Units × 5.5)|
|3–8 yr||34–169 mcg/24 hr||187–930 micromol/day||29–145 mcg/24 hr||160–798 micromol/day|
|9–12 yr||84–422 mcg/24 hr||462–2321 micromol/day||55–277 mcg/24 hr||302–1524 micromol/day|
|13–17 yr||91–456 mcg/24 hr||501–2508 micromol/day||57–286 mcg/24 hr||314–1573 micromol/day|
|Conventional Units||SI Units (Conventional Units × 5.5)|
|Age/Male and Female|
|18–29 yr||103–390 mcg/24 hr||566–2145 micromol/day|
|30–39 yr||111–419 mcg/24 hr||610–2304 micromol/day|
|40–49 yr||119–451 mcg/24 hr||654–2481 micromol/day|
|50–59 yr||128–484 mcg/24 hr||704–2662 micromol/day|
|60–69 yr||138–521 mcg/24 hr||759–2866 micromol/day|
|70 yr and older||148–560 mcg/24 hr||814–3080 micromol/day|
Critical Findings and Potential Interventions
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