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To assist in establishing a diagnosis of breast disease; in the presence of breast cancer, this test is also used to assist in evaluating prognosis and management of response to therapy.
Breast tissue or cells.
(Method: Macroscopic and microscopic examination of tissue for biopsy; cytochemical or immunohistochemical for estrogen and progesterone receptors, Ki67, PCNA, P53; flow cytometry for DNA ploidy and S-phase fraction; immunohistochemical or FISH for Her-2/neu) Fluorescence in situ hybridization (FISH) is a cytogenic technique that uses fluorescent-labelled DNA probes to detect specific chromosome abnormalities. Favorable findings:
- Biopsy: No abnormal cells or tissue.
- DNA ploidy: Majority diploid cell population.
- SPF: Low fraction of replicating cells in total cell population.
- Her-2/neu, Ki67, PCNA, and P53: Negative to low percentage of stained cells.
- Estrogen and progesterone receptors: High percentage of stained cells.
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Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Biopsy, Breast." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425051/all/Biopsy__Breast.
Bladh ML, Van Leeuwen AM. Biopsy, Breast. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425051/all/Biopsy__Breast. Accessed April 21, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Biopsy, Breast. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425051/all/Biopsy__Breast
Bladh ML, Van Leeuwen AM. Biopsy, Breast [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 April 21]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425051/all/Biopsy__Breast.
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