Complement, Total, C3, and C4

Complement, Total, C3, and C4 is a topic covered in the Davis's Lab & Diagnostic Tests.

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Synonym/Acronym:
Total hemolytic complement, CH50, CH100.

Rationale
To detect inborn complement deficiency, evaluate immune diseases related to complement activity, and follow up on a patient's response to therapy such as treatment for rheumatoid arthritis and systemic lupus erythematosus (SLE), in which complement is consumed at an increased rate.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
Method: Quantitative hemolysis for total complement; immunoturbidimetric for C3 and C4.


CH50
100–300 CH50 units/mL

C3
AgeConventional UnitsSI Units (Conventional Units × 0.01)
Newborn57–116 mg/dL0.57–1.16 g/L
6 mo–adult74–166 mg/dL0.74–1.66 g/L
Adult83–177 mg/dL0.83–1.77 g/L

C4
AgeConventional UnitsSI Units (Conventional Units × 0.01)
Newborn10–31 mg/dL0.1–0.31 g/L
6 mo–6 yr15–52 mg/dL0.15–0.52 g/L
7–12 yr19–40 mg/dL0.19–0.4 g/L
13–15 yr19–57 mg/dL0.19–0.57 g/L
16–18 yr19–42 mg/dL0.19–0.42 g/L
Adult12–36 mg/dL0.12–0.36 g/L

Critical Findings and Potential Interventions
N/A

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Synonym/Acronym:
Total hemolytic complement, CH50, CH100.

Rationale
To detect inborn complement deficiency, evaluate immune diseases related to complement activity, and follow up on a patient's response to therapy such as treatment for rheumatoid arthritis and systemic lupus erythematosus (SLE), in which complement is consumed at an increased rate.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
Method: Quantitative hemolysis for total complement; immunoturbidimetric for C3 and C4.


CH50
100–300 CH50 units/mL

C3
AgeConventional UnitsSI Units (Conventional Units × 0.01)
Newborn57–116 mg/dL0.57–1.16 g/L
6 mo–adult74–166 mg/dL0.74–1.66 g/L
Adult83–177 mg/dL0.83–1.77 g/L

C4
AgeConventional UnitsSI Units (Conventional Units × 0.01)
Newborn10–31 mg/dL0.1–0.31 g/L
6 mo–6 yr15–52 mg/dL0.15–0.52 g/L
7–12 yr19–40 mg/dL0.19–0.4 g/L
13–15 yr19–57 mg/dL0.19–0.57 g/L
16–18 yr19–42 mg/dL0.19–0.42 g/L
Adult12–36 mg/dL0.12–0.36 g/L

Critical Findings and Potential Interventions
N/A

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