Biopsy, Bone Marrow
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To assist in diagnosing hematological diseases and in identifying and staging myeloproliferative neoplasms and leukemias.
Bone marrow aspirate, bone core biopsy, marrow and peripheral smears.
(Method: Microscopic study of bone and bone marrow samples, flow cytometry) Reference ranges are subject to many variables, and therefore the laboratory should be consulted for their specific interpretation. Some generalities may be commented on regarding findings as follows:
- Ratio of marrow fat to cellular elements is related to age, with the amount of fat increasing with increasing age.
- Normal cellularity, cellular distribution, presence of megakaryocytes, and absence of fibrosis or tumor cells.
- The myeloid-to-erythrocyte ratio (M:E) is 2:1 to 4:1 in adults. It may be slightly higher in children.
|Differential Parameter||Conventional Units|
|Eosinophils and precursors||1%–5%|
|Basophils and precursors||0%–1%|
|Monocytes and precursors||1%–5%|