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Biopsy, Bone Marrow

Biopsy, Bone Marrow is a topic covered in the Davis's Lab & Diagnostic Tests.

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Common Use:
To assist in diagnosing hematological diseases and in identifying and staging myeloproliferative neoplasms and leukemias.

Bone marrow aspirate, bone core biopsy, marrow and peripheral smears.

Normal Findings:
(Method: Microscopic study of bone and bone marrow samples, flow cytometry) Reference ranges are subject to many variables, and therefore the laboratory should be consulted for their specific interpretation. Some generalities may be commented on regarding findings as follows:

  • Ratio of marrow fat to cellular elements is related to age, with the amount of fat increasing with increasing age.
  • Normal cellularity, cellular distribution, presence of megakaryocytes, and absence of fibrosis or tumor cells.
  • The myeloid-to-erythrocyte ratio (M:E) is 2:1 to 4:1 in adults. It may be slightly higher in children.
Differential ParameterConventional Units
Erythrocyte precursors18%–32%
Eosinophils and precursors1%–5%
Basophils and precursors0%–1%
Monocytes and precursors1%–5%
Plasma cells0%–1%

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Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Biopsy, Bone Marrow." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425120/all/Biopsy__Bone_Marrow.
Bladh ML, Van Leeuwen AM. Biopsy, Bone Marrow. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425120/all/Biopsy__Bone_Marrow. Accessed April 21, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Biopsy, Bone Marrow. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425120/all/Biopsy__Bone_Marrow
Bladh ML, Van Leeuwen AM. Biopsy, Bone Marrow [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 April 21]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425120/all/Biopsy__Bone_Marrow.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Biopsy, Bone Marrow ID - 425120 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425120/all/Biopsy__Bone_Marrow PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -