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Pericardial Fluid Analysis

Synonym/Acronym:
N/A

Rationale
To evaluate and classify the type of fluid between the pericardium membranes to assist with diagnosis of infection or fluid balance disorder.

Patient Preparation
There are no activity restrictions unless by medical direction. Note that food and fluids should be restricted for 6 to 8 hr before the procedure, as directed by the health-care provider (HCP), unless the procedure is performed in an emergency situation to correct pericarditis.

Regarding the patient's risk for bleeding, the patient should be instructed to avoid taking natural products and medications with known anticoagulant, antiplatelet, or thrombolytic properties or to reduce dosage, as ordered, prior to the procedure. Number of days to withhold medication is dependent on the type of anticoagulant. Note the last time and dose of medication taken. Protocols may vary among facilities.

Normal Findings
Method: Spectrophotometry for glucose; automated or manual cell count, macroscopic examination of cultured organisms, and microscopic examination of specimen for microbiology and cytology; microscopic examination of cultured microorganisms.

Pericardial FluidReference Value
AppearanceClear
Color Pale yellow
GlucoseParallels serum values
Red blood cell (RBC) countNone seen
White blood cell (WBC) countLess than 300 cells/microL
CultureNo growth
Gram stainNo organisms seen
CytologyNo abnormal cells seen

Critical Findings and Potential Interventions

  • Positive culture findings in any sterile body fluid.

Timely notification to the requesting HCP of any critical findings and related symptoms is a role expectation of the professional nurse. A listing of these findings varies among facilities.

Overview

(Study type: Body fluid [pericardial fluid] collected in a red- or green-top [heparin] tube for glucose, a lavender-top [EDTA] tube for cell count, and sterile containers for microbiology specimens; fluid in a clear container for cytology; related body system: Circulatory and Immune systems. Ensure that there is an equal amount of fixative and fluid in the container for cytology.) The heart is located within a protective membrane called the pericardium. The fluid between the pericardial membranes is called serous fluid. Normally, only a small amount of fluid is present because the rates of fluid production and absorption are about the same. Many abnormal conditions can result in the buildup of fluid within the pericardium. Specific tests are usually ordered in addition to a common battery of tests used to distinguish a transudate from an exudate. Transudates are effusions that form as a result of a systemic disorder that disrupts the regulation of fluid balance, such as a suspected perforation. Exudates are caused by conditions involving the tissue of the membrane itself, such as an infection or malignancy. Fluid is withdrawn from the pericardium by needle aspiration and tested as listed in the previous and following tables.
CharacteristicTransudateExudate
AppearanceClear to pale yellowCloudy, bloody, or turbid
Specific gravityLess than 1.015Greater than 1.015
Total proteinLess than 2.5 g/dLGreater than 3 g/dL
Fluid protein–to–serum protein ratioLess than 0.5Greater than 0.5
Lactate dehydrogenase (LDH)Less than 2/3 the upper limit of normal serum LDH Greater than 2/3 the upper limit of normal serum LDH
Fluid LDH–to–serum LDH ratioLess than 0.6Greater than 0.6
Fluid cholesterolLess than 55 mg/dLGreater than 55 mg/dL
WBC countLess than 100 cells/microLGreater than 1,000 cells/microL

Indications

  • Evaluate effusion of unknown etiology.
  • Investigate suspected hemorrhage, immune disease, malignancy, or infection.

Interfering Factors

Factors that may alter the results of the study

  • Bloody fluid may be the result of a traumatic tap.

Other Considerations:

  • Unknown hyperglycemia or hypoglycemia may be misleading in the comparison of fluid and serum glucose levels. Therefore, it is advisable to collect comparative serum samples a few hours before performing pericardiocentesis.

Potential Medical Diagnosis: Clinical Significance of Results

Increased In:

Condition/Test Showing Increased Result

  • Bacterial pericarditis (RBC count, WBC count with a predominance of neutrophils)
  • Hemorrhagic pericarditis (RBC count, WBC count)
  • Malignancy (RBC count, abnormal cytology)
  • Post–myocardial infarction syndrome, also called Dressler syndrome (RBC count, WBC count with a predominance of neutrophils)
  • Rheumatoid disease or systemic lupus erythematosus (SLE) (RBC count, WBC count)
  • Tuberculous or fungal pericarditis (RBC count, WBC count with a predominance of lymphocytes)
  • Viral pericarditis (RBC count, WBC count with a predominance of neutrophils)

Decreased In:

Condition/Test Showing Decreased Result

  • Bacterial pericarditis (glucose)
  • Malignancy (glucose)
  • Rheumatoid disease or SLE (glucose)

Nursing Implications

Before the Study: Planning and Implementation

Teaching the Patient What to Expect

  • Inform the patient this procedure can assist with evaluating fluid around the heart.
  • Explain that a pericardial fluid sample is needed for the test.
  • Explain that prior to the procedure, laboratory testing may be required to determine the possibility of bleeding risk (coagulation testing).
  • Explain that reducing health-care-associated infections is an important patient safety goal and a number of different safety practices will be implemented during their procedure. Advise the patient that hair in the area near the catheter insertion site may be clipped or shaved and the area cleaned with an antiseptic solution to cleanse bacteria from the skin in order to reduce the risk for infection. Note: The World Health Organization, Centers for Disease Control and Prevention, and Association of periOperative Registered Nurses recommend that hair not be removed at all unless it interferes with the incision site or other aspects of the procedure because hair removal by any means is associated with increased infection rates. When hair removal is necessary, facilities must use a protocol that is based on scientific literature or the endorsement of a professional organization. Clipping immediately before the procedure and in a location outside the procedure area is preferred to shaving with a razor. Shaving creates a break in skin integrity and provides a way for bacteria on the skin to enter the incision site.
  • Explain that a pericardial fluid sample is needed for the test.
  • Review the procedure with the patient. Address concerns about pain and explain that there may be moments of discomfort or pain experienced when the IV line is inserted to allow infusion of fluids such as saline, anesthetics, sedatives, antibiotics, medications used in the procedure, or emergency medications; a sedative and/or analgesia will be administered to promote relaxation and reduce discomfort prior to needle insertion through the chest wall into the pericardium.
  • Explain that any discomfort with the needle insertion will be minimized with local anesthetics and systemic analgesics.
  • Advise that the anesthetic injection may cause a stinging sensation and that after the skin has been anesthetized, a large needle will be inserted through the chest to obtain the fluid.
  • The specimen collection is performed by an HCP specializing in this procedure and usually takes approximately 30 min to complete.
  • Baseline vital signs are recorded and continuously monitored throughout the procedure. Protocols may vary among facilities.
  • Positioning for this procedure is in a comfortable supine position with the head elevated 45 to 60 degrees.
  • The area is draped, and then the skin at the injection site is anesthetized. Explain that the cardiac needle is inserted just below and to the left of the breastbone, and fluid is removed.
  • Vital signs are monitored every 15 min for signs of hypovolemia or shock.
  • The electrocardiogram is monitored for needle-tip positioning to indicate accidental puncture of the right atrium.
  • Once the procedure is completed, the needle is withdrawn, and slight pressure is applied to the site along with a sterile dressing.
  • Samples are placed in properly labelled specimen containers and promptly transported to the laboratory for processing and analysis.

Potential Nursing Actions

Make sure a written and informed consent has been signed prior to the procedure and before administering any medications.

Safety Considerations

  • Anticoagulants, aspirin, and other salicylates should be discontinued by medical direction for the appropriate number of days prior to a procedure in which bleeding is a potential complication.

After the Study: Potential Nursing Actions

Avoiding Complications

  • Establishing an IV site and performing a pericardiocentesis are invasive procedures. Complications are rare but include risk for bleeding (related to a bleeding disorder, or the effects of natural products and medications with known anticoagulant, antiplatelet, or thrombolytic properties), infection, or injury (related to puncture of surrounding vessels or organs). Monitor the patient for complications related to the procedure (e.g., bleeding, infection, injury). Immediately report the appropriate elevated WBC count, fever, malaise, or tachycardia (indications of infection). Observe/assess the needle insertion site for bleeding, drainage, inflammation, or hematoma formation.

Treatment Considerations

  • Instruct the patient to resume usual diet and medications, as directed by the HCP.
  • Inform the patient that 1 hr or more of bedrest is required after the procedure.
  • Monitor vital signs and cardiac status every 15 min for the first hour, every 30 min for the next 2 hr, every hr for the next 4 hr, and every 4 hr for the next 24 hr. Take the patient's temperature every 4 hr for 24 hr. Monitor intake and output for 24 hr. Notify the HCP if temperature is elevated. Protocols may vary among facilities.
  • Observe for signs of respiratory and cardiac distress, such as shortness of breath, cyanosis, or rapid pulse.
  • Continue IV fluids until vital signs are stable and the patient can resume fluid intake independently.
  • Observe for nausea and pain. Administer antiemetic and analgesic medications as needed and as directed by the HCP.
  • Administer ordered antibiotics and explain the importance of completing the entire course of antibiotic therapy even if no symptoms are present.

Followup Evaluation and Desired Outcomes

  • Understands that further testing, along with a referral to another HCP, may be necessary to manage the disease process and monitor the effectiveness of therapeutic interventions.

Pericardial Fluid Analysis is a sample topic from the Davis's Lab & Diagnostic Tests.

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Citation

Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Pericardial Fluid Analysis." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425127/4/Pericardial_Fluid_Analysis.
Bladh ML, Van Leeuwen AM. Pericardial Fluid Analysis. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425127/4/Pericardial_Fluid_Analysis. Accessed June 19, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Pericardial Fluid Analysis. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425127/4/Pericardial_Fluid_Analysis
Bladh ML, Van Leeuwen AM. Pericardial Fluid Analysis [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 June 19]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425127/4/Pericardial_Fluid_Analysis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Pericardial Fluid Analysis ID - 425127 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425127/4/Pericardial_Fluid_Analysis PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -