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Delta-Aminolevulinic Acid

Delta-Aminolevulinic Acid is a topic covered in the Davis's Lab & Diagnostic Tests.

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δ-ALA, δ-aminolevulinic acid.

To assist in diagnosing lead poisoning in children, or porphyria, a disorder that disrupts heme synthesis, primarily affecting the liver.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction. Usually, a 24-hr urine collection is ordered. As appropriate, provide the required urine collection container and specimen collection instructions.

Normal Findings
Method: Spectrophotometry.

Conventional UnitsSI Units (Conventional Units × 7.626)
1.5–7.5 mg/24 hr11.4–57.2 micromol/24 hr

Critical Findings and Potential Interventions

Signs and symptoms of an acute porphyria attack include pain (commonly in the abdomen, arms, and legs), nausea, vomiting, muscle weakness, rapid pulse, and high blood pressure. Possible interventions include medication for pain, nausea, and vomiting, and, if indicated, respiratory support. Initial treatment following a moderate to severe attack may include identification and cessation of harmful drugs the patient may be taking, IV infusion of glucose, and IV heme therapy (hematin, heme arginate) if indicated by markedly elevated urine δ-ALA and porphyrins.

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Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Delta-Aminolevulinic Acid." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425149/all/Delta_Aminolevulinic_Acid.
Bladh ML, Van Leeuwen AM. Delta-Aminolevulinic Acid. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425149/all/Delta_Aminolevulinic_Acid. Accessed July 17, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Delta-Aminolevulinic Acid. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425149/all/Delta_Aminolevulinic_Acid
Bladh ML, Van Leeuwen AM. Delta-Aminolevulinic Acid [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 July 17]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425149/all/Delta_Aminolevulinic_Acid.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Delta-Aminolevulinic Acid ID - 425149 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425149/all/Delta_Aminolevulinic_Acid PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -