Alkaline Phosphatase and Isoenzymes

Alkaline Phosphatase and Isoenzymes is a topic covered in the Davis's Lab & Diagnostic Tests.

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General

Synonym/Acronym:
Alk Phos, ALP and fractionation, heat-stabile ALP.

Common Use:
To assist in the diagnosis of liver cancer and cirrhosis, or bone cancer and bone fracture.

Specimen:
Serum collected in a gold-, red-, or red/gray-top tube. Plasma collected in a green-top (heparin) tube is also acceptable.

Normal Findings:
(Method: Spectrophotometry for total alkaline phosphatase, inhibition/electrophoresis for fractionation)

Age/GenderTotal ALP Conventional & SI UnitsBone Fraction Conventional & SI UnitsLiver Fraction Conventional & SI Units
0–30 d
 Male75–375 units/LNANA
 Female65–350 units/LNANA
1–11 mo
 Male70–350 units/LNANA
 Female80–330 units/LNANA
1–5 yr
 Male56–350 units/L39–308 units/LLess than 8–101 units/L
 Female73–378 units/L56–300 units/LLess than 8–53 units/L
6–7 yr
 Male70–364 units/L50–319 units/LLess than 8–76 units/L
 Female73–378 units/L56–300 units/LLess than 8–53 units/L
8 yr
 Male70–364 units/L50–258 units/LLess than 8–62 units/L
 Female98–448 units/L78–353 units/LLess than 8–62 units/L
9–12 yr
 Male112–476 units/L78–339 units/LLess than 8–81 units/L
 Female98–448 units/L78–353 units/LLess than 8–62 units/L
13 yr
 Male112–476 units/L78–389 units/LLess than 8–48 units/L
 Female56–350 units/L28–252 units/LLess than 8–50 units/L
14 yr
 Male112–476 units/L78–389 units/LLess than 8–48 units/L
 Female56–266 units/L31–190 units/LLess than 8–48 units/L
15 yr
 Male70–378 units/L48–311 units/LLess than 8–39 units/L
 Female42–168 units/L20–115 units/LLess than 8–53 units/L
16 yr
 Male70–378 units/L48–311 units/LLess than 8–39 units/L
 Female28–126 units/L14–87 units/LLess than 8–50 units/L
17 yr
 Male56–238 units/L34–190 units/LLess than 8–39 units/L
 Female28–126 units/L17–84 units/LLess than 8–53 units/L
18 yr
 Male56–182 units/L34–146 units/LLess than 8–39 units/L
 Female28–126 units/L17–84 units/LLess than 8–53 units/L
19 yr
 Male42–154 units/L25–123 units/LLess than 8–39 units/L
 Female28–126 units/L17–84 units/LLess than 8–53 units/L
20 yr
 Male45–138 units/L25–73 units/LLess than 8–48 units/L
 Female33–118 units/L17–56 units/LLess than 8–50 units/L
21 yr and older
 Male35–142 units/L11–73 units/L0–93 units/L
 Female25–125 units/L11–73 units/L0–93 units/L
Values may be slightly elevated in older adults.

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Citation

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TY - ELEC T1 - Alkaline Phosphatase and Isoenzymes ID - 425184 Y1 - 2017 PB - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425184/all/Alkaline_Phosphatase_and_Isoenzymes ER -