Cold Agglutinin Titer
is a topic covered in the Davis's Lab & Diagnostic Tests
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To identify and confirm the presence of viral infections such as found in atypical pneumonia.
Serum collected in a red-top tube. The tube must be placed in a water bath or heat block at 37°C for 1 hr and allowed to clot before the serum is separated from the red blood cells (RBCs).
(Method: Patient serum containing autoantibodies titered against type O RBCs at 2°C to 8°C. Type O cells are used because they have no antigens on the cell membrane surface. Agglutination with patient sera would not occur because of reaction between RBC blood type antigens and patient blood type antibodies.) Negative: Single titer less than 1:32 or less than a fourfold increase in titer over serial samples. High titers may appear spontaneously in older adult patients and persist for many years.
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Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Cold Agglutinin Titer." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425227/all/Cold_Agglutinin_Titer.
Bladh ML, Van Leeuwen AM. Cold Agglutinin Titer. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425227/all/Cold_Agglutinin_Titer. Accessed April 22, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Cold Agglutinin Titer. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425227/all/Cold_Agglutinin_Titer
Bladh ML, Van Leeuwen AM. Cold Agglutinin Titer [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 April 22]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425227/all/Cold_Agglutinin_Titer.
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