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Alzheimer’s Disease Markers

Alzheimer’s Disease Markers is a topic covered in the Davis's Lab & Diagnostic Tests.

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General

Synonym/Acronym:
CSF tau protein and β-amyloid-42, AD, APP, PS-1, PS-2, Apo E4.

Common Use:
To assist in diagnosing Alzheimer’s disease and monitoring the effectiveness of therapy.

Specimen:
Cerebrospinal fluid (CSF) collected in a plain plastic conical tube for tau protein and β-amyloid-42; whole blood from one full lavender-top (EDTA) tube for apolipoprotein E4 (ApoE4) genotyping, β-amyloid precursor protein, presenilin 1, and presenilin 2.

Normal Findings:
(Method: Enzyme-linked immunosorbent assay) Simultaneous tau protein and β-amyloid-42 measurements in CSF are used in conjunction with detection of apolipoprotein E4 alleles (restriction fragment length polymorphism) and identification of mutations in the β-amyloid precursor protein (APP), presenilin 1 (PS-1) and presenilin 2 (PS-2) genes (polymerase chain reaction and DNA sequencing) as biochemical and genetic markers of Alzheimer’s disease (AD). Scientific studies indicate that a combination of elevated tau protein and decreased β-amyloid-42 protein levels are consistent with the presence of AD. The testing laboratory should be consulted for interpretation of results.

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Citation

Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Alzheimer’s Disease Markers." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer’s_Disease_Markers.
Bladh ML, Van Leeuwen AM. Alzheimer’s Disease Markers. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer’s_Disease_Markers. Accessed April 21, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Alzheimer’s Disease Markers. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer’s_Disease_Markers
Bladh ML, Van Leeuwen AM. Alzheimer’s Disease Markers [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 April 21]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer’s_Disease_Markers.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Alzheimer’s Disease Markers ID - 425237 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer’s_Disease_Markers PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -