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Alzheimer Disease Markers

Alzheimer Disease Markers is a topic covered in the Davis's Lab & Diagnostic Tests.

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Nursing Central

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Synonym/Acronym:
CSF tau protein and β-amyloid-42, AD, APP, PS-1, PS-2, Apo E4.

Rationale
To assist in diagnosing Alzheimer disease and monitoring the effectiveness of therapy.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
(Method: Enzyme-linked immunosorbent assay) Simultaneous tau protein and β-amyloid-42 measurements in cerebrospinal fluid (CSF) are used in conjunction with detection of apolipoprotein E4 alleles (restriction fragment length polymorphism) and identification of mutations in the β-amyloid precursor protein (APP), presenilin 1 (PS-1), and presenilin 2 (PS-2) genes (polymerase chain reaction and DNA sequencing) as biochemical and genetic markers of Alzheimer disease (AD). Scientific studies indicate that a combination of elevated tau protein and decreased β-amyloid-42 protein levels are consistent with the presence of AD. The testing laboratory should be consulted for interpretation of results.

Critical Findings and Potential Interventions
N/A

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Citation

Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Alzheimer Disease Markers." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer_Disease_Markers.
Bladh ML, Van Leeuwen AM. Alzheimer Disease Markers. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer_Disease_Markers. Accessed July 17, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Alzheimer Disease Markers. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer_Disease_Markers
Bladh ML, Van Leeuwen AM. Alzheimer Disease Markers [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 July 17]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer_Disease_Markers.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Alzheimer Disease Markers ID - 425237 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer_Disease_Markers PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -