Alzheimer Disease Markers

Alzheimer Disease Markers is a topic covered in the Davis's Lab & Diagnostic Tests.

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Synonym/Acronym:
CSF tau protein and β-amyloid-42, AD, APP, PS-1, PS-2, Apo E4.

Rationale
To assist in diagnosing Alzheimer disease and monitoring the effectiveness of therapy.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
(Method: Enzyme-linked immunosorbent assay) Simultaneous tau protein and β-amyloid-42 measurements in cerebrospinal fluid (CSF) are used in conjunction with detection of apolipoprotein E4 alleles (restriction fragment length polymorphism) and identification of mutations in the β-amyloid precursor protein (APP), presenilin 1 (PS-1), and presenilin 2 (PS-2) genes (polymerase chain reaction and DNA sequencing) as biochemical and genetic markers of Alzheimer disease (AD). Scientific studies indicate that a combination of elevated tau protein and decreased β-amyloid-42 protein levels are consistent with the presence of AD. The testing laboratory should be consulted for interpretation of results.

Critical Findings and Potential Interventions
N/A

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