Alzheimer Disease Markers
is a topic covered in the Davis's Lab & Diagnostic Tests
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CSF tau protein and β-amyloid-42, AD, APP, PS-1, PS-2, Apo E4.
To assist in diagnosing Alzheimer disease and monitoring the effectiveness of therapy.
There are no food, fluid, activity, or medication restrictions unless by medical direction.
(Method: Enzyme-linked immunosorbent assay) Simultaneous tau protein and β-amyloid-42 measurements in cerebrospinal fluid (CSF) are used in conjunction with detection of apolipoprotein E4 alleles (restriction fragment length polymorphism) and identification of mutations in the β-amyloid precursor protein (APP), presenilin 1 (PS-1), and presenilin 2 (PS-2) genes (polymerase chain reaction and DNA sequencing) as biochemical and genetic markers of Alzheimer disease (AD). Scientific studies indicate that a combination of elevated tau protein and decreased β-amyloid-42 protein levels are consistent with the presence of AD. The testing laboratory should be consulted for interpretation of results.
Critical Findings and Potential Interventions
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Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Alzheimer Disease Markers." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer_Disease_Markers.
Bladh ML, Van Leeuwen AM. Alzheimer Disease Markers. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer_Disease_Markers. Accessed July 17, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Alzheimer Disease Markers. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer_Disease_Markers
Bladh ML, Van Leeuwen AM. Alzheimer Disease Markers [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 July 17]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425237/all/Alzheimer_Disease_Markers.
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