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Osmotic Fragility

Osmotic Fragility is a topic covered in the Davis's Lab & Diagnostic Tests.

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General

Synonym/Acronym:
Red blood cell osmotic fragility, OF.

Common Use:
To assess the fragility of erythrocytes related to red blood cell lysis toward diagnosing diseases such as hemolytic anemia.

Specimen:
Whole blood collected in a green-top (heparin) tube and two peripheral blood smears.

Normal Findings:
(Method: Spectrophotometry) Hemolysis (unincubated) begins at 0.5% sodium chloride (NaCl) solution and is complete at 0.3% NaCl solution. Results are compared to a normal curve.

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Citation

Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Osmotic Fragility." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425288/all/Osmotic_Fragility.
Bladh ML, Van Leeuwen AM. Osmotic Fragility. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425288/all/Osmotic_Fragility. Accessed April 21, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Osmotic Fragility. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425288/all/Osmotic_Fragility
Bladh ML, Van Leeuwen AM. Osmotic Fragility [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 April 21]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425288/all/Osmotic_Fragility.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Osmotic Fragility ID - 425288 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425288/all/Osmotic_Fragility PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -