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Coagulation Factors

Coagulation Factors is a topic covered in the Davis's Lab & Diagnostic Tests.

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Nursing Central

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General

Synonym/Acronym:
See table.

Common Use:
To detect factor deficiencies and related coagulopathies such as found in disseminated intravascular coagulation (DIC).

Specimen:
Whole blood collected in a completely filled blue-top (3.2% sodium citrate) tube. If the patient’s hematocrit exceeds 55%, the volume of citrate in the collection tube must be adjusted.

Normal Findings:
(Method: Photo-optical clot detection) Activity from 50% to 150%.

Preferred NameSynonymRole in Modern Coagulation Cascade ModelCoagulation Test Responses in the Presence of Factor Deficiency
Factor IFibrinogenAssists in the formation of the fibrin clotPT prolonged, aPTT prolonged
Factor IIProthrombinPrethrombinAssists factor Xa in formation of trace thrombin in the initiation phase and assists factors VIIIa, IXa, Xa, and Va to form thrombin in the propagation phase of hemostasisPT prolonged, aPTT prolonged
Tissue factor (formerly known as factor III)Tissue factorTissue thromboplastinAssists factor VII and Ca2+ in the activation of factors IX and X during the initiation phase of hemostasisPT prolonged, aPTT prolonged
Calcium (formerly known as factor intravenous)CalciumCa2+Essential to the activation of multiple clotting factorsN/A
Factor VProaccelerinLabile factor, accelerator globulin (AcG)Assists factors VIIIa, IXa, Xa, and II in the formation of thrombin during the amplification and propagation phases of hemostasisPT prolonged, aPTT prolonged
Factor VIIProconvertinStabile factor, serum prothrombin conversion accelerator, autoprothrombin IAssists tissue factor and Ca2+ in the activation of factors IX and XPT prolonged, aPTT normal
Factor VIIIAntihemophilic factor (AHF)Antihemophilic globulin (AHG), antihemophilic factor A, platelet cofactor 1Activated by trace thrombin during the initiation phase of hemostasis to amplify formation of additional thrombinPT normal, aPTT prolonged
Factor IXPlasma thromboplastin component (PTC)Christmas factor, antihemophilic factor B, platelet cofactor 2Assists factors Va and VIIIa in the amplification phase and factors VIIIa, Xa, Va, and II to form thrombin in the propagation phasePT normal, aPTT prolonged
Factor XStuart-Prower factorAutoprothrombin III, thrombokinaseAssists with formation of trace thrombin in the initiation phase and acts with factors VIIIa, IXa, Va, and II to form thrombin in the propagation phasePT prolonged, aPTT prolonged
Factor XIPlasma thromboplastin antecedent (PTA)Antihemophilic factor CActivated by thrombin produced in the extrinsic pathway to enhance production of additional thrombin inside the fibrin clot via the intrinsic pathway; this factor also participates in slowing down the process of fibrinolysisPT normal, aPTT prolonged
Factor XIIHageman factorGlass factor, contact factorContact activator of the kinin system (e.g., prekallikrein, and high-molecular-weight kininogen)PT normal, aPTT prolonged
Factor XIIIFibrin-stabilizing factor (FSF)Laki-Lorand factor (LLF), fibrinase, plasma transglutaminaseActivated by thrombin and assists in formation of bonds between fibrin strands to complete secondary hemostasisPT normal, aPTT normal
von Willebrand factorvon Willebrand factorvWFAssists in platelet adhesion and thrombus formationRistocetin cofactor decreased

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Citation

Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Coagulation Factors." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425298/all/Coagulation_Factors.
Bladh ML, Van Leeuwen AM. Coagulation Factors. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425298/all/Coagulation_Factors. Accessed April 24, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Coagulation Factors. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425298/all/Coagulation_Factors
Bladh ML, Van Leeuwen AM. Coagulation Factors [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 April 24]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425298/all/Coagulation_Factors.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Coagulation Factors ID - 425298 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425298/all/Coagulation_Factors PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -