Apolipoproteins: A, B, and E

Apolipoproteins: A, B, and E is a topic covered in the Davis's Lab & Diagnostic Tests.

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Synonym/Acronym:

Apo A (Apo A1), Apo B (Apo B100), and Apo E.

Rationale

To identify levels of circulating lipoprotein to evaluate the risk of coronary artery disease (CAD).

Patient Preparation

There are no food, fluid, activity, or medication restrictions unless by medical direction. However, if the test is ordered in conjunction with a lipid profile or triglyceride level, instruct the patient to abstain from food for 6 to 12 hr before specimen collection.

Normal Findings

Method: Immunonephelometry for Apo A and Apo B; polymerase chain reaction (PCR) with restriction length enzyme digestion and polyacrylamide gel electrophoresis for Apo E.


Apolipoprotein A-1
AgeConventional UnitsSI Units (Conventional Units × 0.01)
ChildGreater than 120 mg/dLGreater than 1.2 g/L
Adult
  MaleGreater than or equal to 120 mg/dLGreater than 1.2 g/L
  FemaleGreater than or equal to 140 mg/dLGreater than 1.4 g/L

Apolipoprotein B
AgeConventional UnitsSI Units (Conventional Units × 0.01)
2 yr–AdultLess than 90 mg/dLLess than 0.9 g/L

Normal Apo E: Homozygous phenotype for e3/e3.

Critical Findings and Potential Interventions

N/A

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Synonym/Acronym:

Apo A (Apo A1), Apo B (Apo B100), and Apo E.

Rationale

To identify levels of circulating lipoprotein to evaluate the risk of coronary artery disease (CAD).

Patient Preparation

There are no food, fluid, activity, or medication restrictions unless by medical direction. However, if the test is ordered in conjunction with a lipid profile or triglyceride level, instruct the patient to abstain from food for 6 to 12 hr before specimen collection.

Normal Findings

Method: Immunonephelometry for Apo A and Apo B; polymerase chain reaction (PCR) with restriction length enzyme digestion and polyacrylamide gel electrophoresis for Apo E.


Apolipoprotein A-1
AgeConventional UnitsSI Units (Conventional Units × 0.01)
ChildGreater than 120 mg/dLGreater than 1.2 g/L
Adult
  MaleGreater than or equal to 120 mg/dLGreater than 1.2 g/L
  FemaleGreater than or equal to 140 mg/dLGreater than 1.4 g/L

Apolipoprotein B
AgeConventional UnitsSI Units (Conventional Units × 0.01)
2 yr–AdultLess than 90 mg/dLLess than 0.9 g/L

Normal Apo E: Homozygous phenotype for e3/e3.

Critical Findings and Potential Interventions

N/A

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