Cholinesterases: Acetylcholinesterase, Pseudocholinesterase and Dibucaine Number
Cholinesterase: CHS; Acetylcholinesterase: AcCHS, RBC or red blood cell cholinesterase, erythrocyte cholinesterase, true cholinesterase; Pseudocholinesterase: PCHE.
To assess for acquired or inherited pseudocholinesterase deficiency.
There are no food, fluid, activity, or medication restrictions unless by medical direction.
Method: Spectrophotometry, kinetic.
|Acetylcholinesterase (AcCHS)/RBC cholinesterase||25–50 U/g Hgb|
|Dibucaine Number||Fraction (%) of Activity Inhibited|
Critical Findings and Potential Interventions
- A positive PCHE result indicates that the patient is at risk for prolonged or unrecoverable apnea related to the inability to metabolize succinylcholine. Notify the anesthesiologist if the test result is positive and surgery is scheduled.
Timely notification to the requesting health-care provider (HCP) of any critical findings and related symptoms is a role expectation of the professional nurse. A listing of these findings varies among facilities.
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