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Antinuclear Antibody, Anti-DNA Antibody, Anticentromere Antibody, Antiextractable Nuclear Antigen Antibody, Anti-Jo Antibody, and Antiscleroderma Antibody

Antinuclear Antibody, Anti-DNA Antibody, Anticentromere Antibody, Antiextractable Nuclear Antigen Antibody, Anti-Jo Antibody, and Antiscleroderma Antibody is a topic covered in the Davis's Lab & Diagnostic Tests.

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Synonym/Acronym:
Antinuclear antibodies (ANA), anti-DNA (anti-ds DNA), antiextractable nuclear antigens (anti-ENA, ribonucleoprotein [RNP], Smith [Sm], SS-A/Ro, SS-B/La), anti-Jo (antihistidyl transfer RNA [tRNA] synthase), and antiscleroderma (progressive systemic sclerosis [PSS] antibody, Scl-70 antibody, topoisomerase I antibody).

Rationale
To diagnose multiple systemic autoimmune disorders; primarily used for diagnosing systemic lupus erythematosus (SLE).

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
Method: Indirect fluorescent antibody for ANA and anticentromere; Immunoassay multiplex flow for anti-DNA, anti-ENA, anti-Scl-70, and anti-Jo-1.

ANA and anticentromere: Titer of 1:40 or less. Anti-ENA, anti-Jo-1, and anti-Scl-70: Negative. Reference ranges for anti-DNA, anti-ENA, anti-Scl-70, and anti-Jo-1 vary widely due to differences in methods, and the testing laboratory should be consulted directly.


Anti-DNA
NegativeLess than 5 international units
Indeterminate5–9 international units
PositiveGreater than 9 international units

Critical Findings and Potential Interventions
N/A

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Citation

Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Antinuclear Antibody, Anti-DNA Antibody, Anticentromere Antibody, Antiextractable Nuclear Antigen Antibody, Anti-Jo Antibody, and Antiscleroderma Antibody." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425420/all/Antinuclear_Antibody__Anti_DNA_Antibody__Anticentromere_Antibody__Antiextractable_Nuclear_Antigen_Antibody__Anti_Jo_Antibody__and_Antiscleroderma_Antibody.
Bladh ML, Van Leeuwen AM. Antinuclear Antibody, Anti-DNA Antibody, Anticentromere Antibody, Antiextractable Nuclear Antigen Antibody, Anti-Jo Antibody, and Antiscleroderma Antibody. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425420/all/Antinuclear_Antibody__Anti_DNA_Antibody__Anticentromere_Antibody__Antiextractable_Nuclear_Antigen_Antibody__Anti_Jo_Antibody__and_Antiscleroderma_Antibody. Accessed July 17, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Antinuclear Antibody, Anti-DNA Antibody, Anticentromere Antibody, Antiextractable Nuclear Antigen Antibody, Anti-Jo Antibody, and Antiscleroderma Antibody. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425420/all/Antinuclear_Antibody__Anti_DNA_Antibody__Anticentromere_Antibody__Antiextractable_Nuclear_Antigen_Antibody__Anti_Jo_Antibody__and_Antiscleroderma_Antibody
Bladh ML, Van Leeuwen AM. Antinuclear Antibody, Anti-DNA Antibody, Anticentromere Antibody, Antiextractable Nuclear Antigen Antibody, Anti-Jo Antibody, and Antiscleroderma Antibody [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 July 17]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425420/all/Antinuclear_Antibody__Anti_DNA_Antibody__Anticentromere_Antibody__Antiextractable_Nuclear_Antigen_Antibody__Anti_Jo_Antibody__and_Antiscleroderma_Antibody.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Antinuclear Antibody, Anti-DNA Antibody, Anticentromere Antibody, Antiextractable Nuclear Antigen Antibody, Anti-Jo Antibody, and Antiscleroderma Antibody ID - 425420 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425420/all/Antinuclear_Antibody__Anti_DNA_Antibody__Anticentromere_Antibody__Antiextractable_Nuclear_Antigen_Antibody__Anti_Jo_Antibody__and_Antiscleroderma_Antibody PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -