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Newborn Screening

Newborn Screening is a topic covered in the Davis's Lab & Diagnostic Tests.

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NBS, newborn metabolic screening, tests for inborn errors of metabolism, early hearing loss detection and intervention for newborns.

Common Use:
To evaluate newborns for congenital abnormalities, which may include hearing loss; identification of hemoglobin variants such as thalassemias and sickle cell anemia; presence of antibodies that would indicate a HIV infection; or metabolic disorders such as homocystinuria, maple syrup urine disease (MSUD), phenylketonuria (PKU), tyrosinuria, and unexplained physical or intellectual disabilities.

Area Of Application:
Ears for hearing tests.

Whole blood for metabolic tests.

Normal Findings:
(Method: Thyroxine, TSH, and HIV—immunoassay; amino acids—tandem mass spectrometry; hemoglobin variants—electrophoresis)

Hearing Test
AgeNormal Findings
Neonates–3 dNormal pure tone average of –10 to 15 dB
Thyroid-Stimulating Hormone (TSH)
AgeConventional UnitsSI Units (Conventional Units × 1)
Neonates–3 dLess than 40 micro-international units/mLLess than 40 milli-international units/L
Thyroxine, Total
AgeConventional UnitsSI Units (Conventional Units × 12.9)
Neonates–30 d5.4–22.6 mcg/dL69.7–291.5 nmol/L
HemoglobinopathiesNormal Hemoglobin Pattern
Blood spot amino acid analysisNormal findings. Numerous amino acids are evaluated by blood spot testing, and values vary by method and laboratory. The testing laboratory should be consulted for corresponding reference ranges.
HIV antibodiesNegative

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Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Newborn Screening." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425429/all/Newborn_Screening.
Bladh ML, Van Leeuwen AM. Newborn Screening. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425429/all/Newborn_Screening. Accessed April 23, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Newborn Screening. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425429/all/Newborn_Screening
Bladh ML, Van Leeuwen AM. Newborn Screening [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 April 23]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425429/all/Newborn_Screening.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Newborn Screening ID - 425429 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425429/all/Newborn_Screening PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -