Antineutrophil Cytoplasmic Antibody (P-ANCA, C-ANCA)

General

Synonym/Acronym:
cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA), perinuclear antineutrophil cytoplasmic antibody (p-ANCA).

Rationale
To assist in diagnosis and monitoring of therapeutic interventions for glomerulonephritis, vasculitis, and granulomatosis with polyangiitis (GPA) (formerly Wegener granulomatosis [WG]).

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.

Normal Findings
(Method: Indirect immunofluorescence for ANCA, both types) Negative; Multiplex Flow Immunoassay for Proteinase 3 antibodies.

Antineutrophil Cytoplasmic Antibodies
P-ANCA or C-ANCANegative
Proteinase 3 Antibodies
Less than 0.4 UNegative
0.4-0.9 UEquivocal
Greater than or equal to 1 UPositive

Critical Findings and Potential Interventions
N/A

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