Antineutrophil Cytoplasmic Antibody (P-ANCA, C-ANCA)
General
Synonym/Acronym:
cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA), perinuclear antineutrophil cytoplasmic antibody (p-ANCA).
Rationale
To assist in diagnosis and monitoring of therapeutic interventions for glomerulonephritis, vasculitis, and granulomatosis with polyangiitis (GPA) (formerly Wegener granulomatosis [WG]).
Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction.
Normal Findings
(Method: Indirect immunofluorescence for ANCA, both types) Negative; Multiplex Flow Immunoassay for Proteinase 3 antibodies.
Antineutrophil Cytoplasmic Antibodies | |
P-ANCA or C-ANCA | Negative |
Proteinase 3 Antibodies | |
Less than 0.4 U | Negative |
0.4-0.9 U | Equivocal |
Greater than or equal to 1 U | Positive |
Critical Findings and Potential Interventions
N/A
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