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Maternal Markers

Maternal Markers is a topic covered in the Davis's Lab & Diagnostic Tests.

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α1-Fetoprotein, cell-free DNA screening, maternal serum screening tests, prenatal screening tests, quad testing (AFP, HCG, estriol, inhibin-A), triple markers (AFP, HCG, estriol).

To assist in the evaluation of fetal health related to chromosomal (e.g., trisomy 18, trisomy 21) or neural tube defects (e.g., spina bifida, anencephaly).

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction or as required by the specific collection procedure.

Normal Findings
Each testing laboratory must establish its own reference ranges for quantitative measurements and its own cutoffs for negative and positive findings. Findings are then issued by laboratory report. Serum values for the tests evaluated vary with maternal race, weight, weeks of gestation, diabetic status, and number of fetuses. Variations exist between test methods; therefore, serial testing should be determined using the same test method. The calculated risk of a trisomy is based on the multiples of the median (MoM) of multiple markers, where the MoM is calculated for each marker and applied to an algorithm that includes other information known to influence the incidence of trisomy.

Critical Findings and Potential Interventions

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Bladh, Mickey Lynn., and Anne M. Van Leeuwen. "Maternal Markers." Davis's Lab & Diagnostic Tests, 7th ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425481/all/Maternal_Markers.
Bladh ML, Van Leeuwen AM. Maternal Markers. Davis's Lab & Diagnostic Tests. 7th ed. F.A. Davis Company; 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425481/all/Maternal_Markers. Accessed June 20, 2019.
Bladh, M. L., & Van Leeuwen, A. M. (2017). Maternal Markers. In Davis's Lab & Diagnostic Tests. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425481/all/Maternal_Markers
Bladh ML, Van Leeuwen AM. Maternal Markers [Internet]. In: Davis's Lab & Diagnostic Tests. F.A. Davis Company; 2017. [cited 2019 June 20]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425481/all/Maternal_Markers.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Maternal Markers ID - 425481 A1 - Bladh,Mickey Lynn, AU - Van Leeuwen,Anne M, BT - Davis's Laboratory & Diagnostic Tests UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425481/all/Maternal_Markers PB - F.A. Davis Company ET - 7 DB - Nursing Central DP - Unbound Medicine ER -