Antiphospholipid Antibodies (aPL): Anticardiolipin Antibody, IgG, and IgM; Anti–beta-2 glycoprotein 1, IgG and IgM; Lupus Anticoagulant, IgG and IgM

General

Synonym/Acronym:
anticardiolipin antibody (ACA); anti–beta-2 glycoprotein 1 (Beta-2 GP1), apolipoprotein H; lupus anticoagulant (LA, lupus antiphospholipid antibodies, lupus inhibitor phospholipid type).

Rationale
To detect the presence of antiphospholipid antibodies, which can lead to the development of blood vessel problems (thrombosis), systemic lupus erythematosus (SLE), and complications including stroke, heart attack, and miscarriage.

Patient Preparation
There are no food, fluid, activity, or medication restrictions unless by medical direction for ACA and beta-2 GP1.

There are no food, fluid, or activity restrictions unless by medical direction for LA. Heparin or Warfarin (Coumadin) therapy should be noted on the test request or discontinued before LA specimen collection, with medical direction.

Normal Findings
Method: Enzyme-linked immunosorbent assay (ELISA) for ACA: and beta-2 GP1: Negative (Less than 15 GPL); Dilute Russell viper venom test time for LA: Ratio less than 1.2 (value of patient sample/value of normal control sample).

Critical Findings and Potential Interventions
N/A

There's more to see -- the rest of this topic is available only to subscribers.