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Cor Pulmonale


DRG Category: 315

Mean LOS: 3.8 days

Description MEDICAL: Other Circulatory System Diagnoses With CC

Classification Section

Nursing Type Primary: acute care

Nursing Type Secondary: critical care

System Primary: cardiovascular

System Secondary: pulmonary


Cor pulmonale is right-sided hypertrophy of the heart caused by pulmonary hypertension, a primary disorder of the respiratory system. Cor pulmonale is estimated to cause approximately 5% to 7% of all types of heart disease in adults, and chronic obstructive pulmonary disease (COPD) due to chronic bronchitis or emphysema is the causative factor in more than 50% of people with cor pulmonale. While it is difficult to know how many people in the United States have cor pulmonale, experts estimate that 15 million people have the condition. It causes increases in pulmonary vascular resistance, and as the right side of the heart works harder, the right ventricle hypertrophies. An increase in pulmonary vascular resistance is the result of anatomic reduction of the pulmonary vascular bed, pulmonary vasoconstriction, or abnormalities of ventilatory mechanics.

A number of physiological changes lead to poor gas exchange. Alveolar wall damage results in anatomic reduction of the pulmonary vascular bed as the number of pulmonary capillaries are reduced and the vasculature stiffens from pulmonary fibrosis. Constriction of the pulmonary vessels and hypertrophy of vessel tissue are caused by alveolar hypoxia and hypercapnia. Abnormalities of the ventilatory mechanics bring about compression of pulmonary capillaries. Cor pulmonale accounts for approximately 25% of all types of heart failure. Complications of cor pulmonale include biventricular heart failure, hepatomegaly, pleural effusion, and thromboembolism related to polycythemia.


Acute cor pulmonale is produced by a number of other pulmonary and pulmonary vascular disorders but primarily by acute respiratory distress syndrome (ARDS) and pulmonary embolism. Two factors in ARDS lead to right ventricular overload: the disease itself and the high transpulmonary pressures that are needed to treat ARDS with mechanical ventilation. In the United States, approximately 25,000 sudden deaths occur per year from heart failure associated with pulmonary emboli. Other conditions can also lead to cor pulmonale. Respiratory insufficiency–such as chest wall disorders, upper airway obstruction, obesity hypoventilation syndrome, and chronic mountain sickness caused by living at high altitudes–can also lead to the chronic forms of the disease. It can also develop from lung tissue loss after extensive lung surgery. A contributing factor is chronic hypoxia, which stimulates erythropoiesis, thus increasing blood viscosity. Cigarette smoking is also a risk factor.

Genetic Considerations

No clear genetic contributions to susceptibility have been defined.

Gender, Ancestry, and Life Span Considerations

Middle-aged to elderly men are more likely to experience cor pulmonale, but incidence in women is increasing. In children, cor pulmonale is likely to be a complication of cystic fibrosis, hemosiderosis, upper airway obstruction, scleroderma, extensive bronchiectasis, neurological diseases that affect the respiratory muscles, or abnormalities of the respiratory control center. No racial or ethnic considerations are known.

Global Health Considerations

The prevalence of cor pulmonale around the world depends on the prevalence of cigarette smoking and other tobacco use, air pollution, toxic exposure, and other risk factors for lung diseases. Global data are not available from developing nations.



Ask the patient to describe any history or cardiopulmonary disease. Determine if the patient has experienced orthopnea, cough, fatigue, epigastric distress, anorexia, or weight gain or has a history of previously diagnosed lung disorders. Ask if the patient smokes cigarettes, noting the daily consumption and duration. Ask about the color and quantity of the mucus the patient expectorates. Determine the amount and type of dyspnea and if it is related only to exertion or is continuous.

Physical Examination

The patient may appear acutely ill with severe dyspnea at rest and visible peripheral edema. Observe if the patient has difficulty in maintaining breath while the history is taken. Evaluate the rate, type, and quality of respirations. Examine the underside of the patient's tongue, buccal mucosa, and conjunctiva for signs of central cyanosis, a finding in congestive heart failure. Oral mucous membranes in dark-skinned individuals are ashen when the patient is cyanotic. Observe the patient for dependent edema from the abdomen (ascites) and buttocks and down both legs.

Inspect the patient's chest and thorax for the general appearance and anteroposterior diameter. Look for the use of accessory muscles in breathing. If the patient can be supine, check for evidence of normal jugular vein protrusion. Place the patient in a semi-Fowler position with his or her head turned away from you. Use a light from the side, which casts shadows along the neck, and look for jugular vein distention and pulsation. Continue looking at the jugular veins and determine the highest level of pulsation using your fingers to measure the number of finger-breadths above the angle of Louis.

While the patient is in semi-Fowler position with the side lighting still in place, look for chest wall movement, visible pulsations, and exaggerated lifts and heaves in all areas of the precordium. Locate the point of maximum impulse (at the fifth intercostal space, just medial of the midclavicular line) and take the apical pulse for a full minute. Listen for abnormal heart sounds. Hypertrophy of the right side of the heart causes a delayed conduction time and deviation of the heart from its axis, which can result in dysrhythmias. With the diaphragm of the stethoscope, auscultate heart sounds in the aortic, pulmonic, tricuspid, and mitral areas. In cor pulmonale, there is an accentuation of the pulmonic component of the second heart sound. The S3 and S4 sounds resemble a horse gallop. The presence of the fourth heart sound is found in cor pulmonale. Auscultate the patient's lungs, listening for normal and abnormal breath sounds. Listen for bibasilar rales and other adventitious sounds throughout the lung fields.


The patient has had to live with the anxiety of shortness of breath for a long time. Chronic hypoxia can lead to restlessness and confusion, and the patient may seem irritated or angry during the physical examination.

Diagnostic Highlights

TestNormal ResultAbnormality With ConditionExplanation
Chest x-raysNormal heart size and clear lungsEnlarged right ventricle and pulmonary artery; may show pneumoniaDemonstrate right-sided hypertrophy of heart and possibly pulmonary infection with other underlying pulmonary abnormalities
Electrocardiogram (ECG)Normal electrocardiographic wave form with P, Q, R, S, T wavesTo reveal increased P-wave amplitude (P-pulmonale) in leads II, III, and a ventricular failure seen in right-axis deviation and incomplete right bundle branch blockChanges in cardiac conduction due to right-sided hypertrophy
EchocardiographyNormal heart sizeTo show ventricular hypertrophy, decreased contractility, and valvular disorders in both right and left ventricular failureDemonstrates heart hypertrophy and tricuspid valve malfunction if present

Other Tests: Magnetic resonance imaging; ultrafast, ECG-gated computed tomography scanning; ventilation/perfusion (V/Q) lung scanning; complete blood count, coagulation profile, arterial blood gases; brain natriuretic peptide (may be elevated due to elevated pulmonary hypertension and right-sided heart failure or in decompensated left ventricular heart failure)

Primary Nursing Diagnosis

Diagnosis: Decreased cardiac output related to an ineffective ventricular pump as evidenced by dyspnea at rest and/or peripheral edema

Outcomes: Cardiac pump: Effectiveness; Circulation status; Tissue perfusion: Abdominal organs and peripheral; Vital sign status; Electrolyte and acid-base balance; Endurance; Energy conservation; Fluid balance

Interventions: Cardiac care; Circulatory care: Mechanical assist device; Fluid/electrolyte management; Medication administration; Medication management; Oxygen therapy; Vital signs monitoring

Planning Implementation


The patient with an acute exacerbation of cor pulmonary requires mechanical ventilation and is usually admitted to an intensive care unit. Patients admitted with heart failure related to ARDS or pulmonary embolism who require specialized treatment, such as hemodynamic monitoring, may also be admitted to a special care unit.

Specific medical treatment for cor pulmonale consists of reversing hypoxia with low-flow oxygen and improving right ventricular function, depending on the underlying cause. In the case of acute cor pulmonale associated with pulmonary emboli, higher concentrations of oxygen may be used. The physician seeks to correct fluid, electrolyte, and acid-base disturbances and may prescribe fluid and sodium restrictions to reduce plasma volume and the work of the heart. In the setting of right ventricular failure, therapies may include vasopressor medications and fluid loading to maintain blood pressure. Single-lung or double-lung transplantation may be considered for people with terminal disease.

SUPPORTIVE CARE. Respiratory therapists provide bronchodilator therapy and may need to teach or reinforce the patient's use of breathing strategies. Therapists may also teach energy conservation. A dietitian confers with the patient and family about the need for low-sodium foods and small, nutritious servings. Specific nutritional deficiencies may need to be corrected as well. Depending on the derivation of cor pulmonale, fluids need to be limited to 1,000 to 1,500 mL per day to prevent fluid retention. Social service agencies will probably be needed for a consultation as well because cor pulmonale creates long-term disability with the likelihood that the patient has not been employed for some time. Unless the patient is old enough to receive Medicare, hospitalization costs are a serious concern.

Pharmacologic Highlights:

Medication or Drug ClassDosageDescriptionRationale
Calcium channel blockersVaries with drugNifedipine, diltiazemLower pulmonary pressures
BronchodilatorsVaries with drugBeta2-adrenergic agonists, anticholinergicsRelieve bronchospasm

Other Drugs: Diuretics are used when right ventricular pressures are elevated, but they are used cautiously so that cardiac output does not decrease. Massive pulmonary embolism may require thrombolytic agents. Oxygen therapy, vasodilators, low-dose digitalis, theophylline, antidysrhythmic agents, prostacyclin analogues and receptor agonists, endothelin receptor antagonists, and anticoagulation therapy may be used in long-term management.


The patient requires bedrest and assistance with the activities of daily living if hypoxemia and hypercapnia are severe. Provide meticulous skin care. Reposition the bedridden patient frequently to prevent atelectasis. Reinforce proper breathing strategies for the patient: breathe in through the nose and out slowly through pursed lips, using abdominal muscles to squeeze out the air; inhale before beginning an activity and then exhale while doing the activity, such as walking or eating.

Nurses can teach patients to control their anxiety, which affects their breathlessness and fear. Teach the patient the use of relaxation techniques. Because patients are continually breathless, they become anxious if they feel rushed; focus on providing a calm approach. Help reduce the patient's fear of exertional dyspnea by providing thoughtful care that builds trust. Encourage the patient to progress in small increments.

Because of the exertion that talking requires, many patients with cor pulmonale may not be able to respond adequately in conversation. Try to understand the patient's reluctance to "tire out" and become familiar with reflective techniques that allow a patient to respond briefly. Integrate your teaching into the care to avoid the need to give the patient too much information to assimilate at the time of discharge.

Evidence Based Practice Health Policy

Xu, W., Yao, J., & Chen, L. (2016). Anxiety in patients with chronic cor pulmonale and its effect on exercise capacity. Iranian Journal of Public Health, 45(8), 1004–1011.

  • The authors studied 160 people with cor pulmonale to determine their level of anxiety and how it affected their exercise capacity as well as several physiological measures. The study included 95 male and 65 female patients.
  • The authors found that almost half of the patients (48.8%) had symptoms of anxiety, and the patients with anxiety had higher heart rates, higher systolic blood pressures, and a faster respiratory rate. Anxious patients also walked a shorter distance when given the 6-minute walk test. The authors recommended a careful assessment of anxiety in cor pulmonale patients.

Documentation Guidelines

  • Physical findings: Vein distention, presence of peripheral edema, cardiopulmonary assessment
  • Responses to activity, treatments, and medications
  • Understanding of and willingness to carry out prescribed therapy

Discharge and Home Healthcare Guidelines

COMPLICATIONS. Teach the patient and family the signs and symptoms of infection, such as increased sputum production, change in sputum color, increased coughing or wheezing, chest pain, fever, and tightness in the chest. Teach the patient how to recognize signs of edema. Make sure the patient knows to call the physician upon recognizing these signs.

MEDICATIONS. Be sure the patient understands any pain medication prescribed, including dosage, route, action, and side effects.

NUTRITION. Explain the importance of maintaining a low-sodium diet. Review nutrition counseling and the prescribed fluid intake.

ONGOING OXYGEN THERAPY. If the patient is going home with low-flow oxygen, ensure that an appropriate vendor is contacted. Determine whether a home care agency needs to evaluate the home for safety equipment and pollution factors.

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Sommers, Marilyn Sawyer.. "Cor Pulmonale." Diseases and Disorders, 6th ed., F.A. Davis Company, 2019. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Diseases-and-Disorders/73563/all/Cor_Pulmonale.
Sommers MS. Cor Pulmonale. Diseases and Disorders. 6th ed. F.A. Davis Company; 2019. https://nursing.unboundmedicine.com/nursingcentral/view/Diseases-and-Disorders/73563/all/Cor_Pulmonale. Accessed April 22, 2019.
Sommers, M. S. (2019). Cor Pulmonale. In Diseases and Disorders. Available from https://nursing.unboundmedicine.com/nursingcentral/view/Diseases-and-Disorders/73563/all/Cor_Pulmonale
Sommers MS. Cor Pulmonale [Internet]. In: Diseases and Disorders. F.A. Davis Company; 2019. [cited 2019 April 22]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Diseases-and-Disorders/73563/all/Cor_Pulmonale.
* Article titles in AMA citation format should be in sentence-case
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