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[mucopolysaccharide + -osis]
ABBR: MPS Any of a group of inherited disorders characterized by a deficiency of enzymes that are essential for the degradation of the mucopolysaccharides heparan sulfate, dermatan sulfate, and keratan sulfate. These chemicals are excreted in excess quantities in the urine, and they usually accumulate in macrophages, the central nervous system, endothelial cells, intimal smooth muscle cells, and fibroblasts throughout the body. Clinical changes are not usually apparent at birth, but the inherited defect can be diagnosed prior to birth by culturing amniotic fluid cells and testing them for specific enzyme activity. After birth, the conditions may be diagnosed by testing cultured skin fibroblasts for specific enzymes. Some MPS may be treated with bone marrow transplantation.
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Venes, Donald, editor. "Mucopolysaccharidosis." Taber's Medical Dictionary, 24th ed., F.A. Davis Company, 2021. Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/729556/all/mucopolysaccharidosis_IV.
Mucopolysaccharidosis. In: Venes DD, ed. Taber's Medical Dictionary. F.A. Davis Company; 2021. https://nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/729556/all/mucopolysaccharidosis_IV. Accessed June 2, 2023.
Mucopolysaccharidosis. (2021). In Venes, D. (Ed.), Taber's Medical Dictionary (24th ed.). F.A. Davis Company. https://nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/729556/all/mucopolysaccharidosis_IV
Mucopolysaccharidosis [Internet]. In: Venes DD, editors. Taber's Medical Dictionary. F.A. Davis Company; 2021. [cited 2023 June 02]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/729556/all/mucopolysaccharidosis_IV.
* Article titles in AMA citation format should be in sentence-case
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