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[1an- + gamma globulin + -emia]
Any of the disorders marked by an almost complete lack of immunoglobulins or antibodies. Agammaglobulinemias are caused by abnormal B lymphocyte function; they cause severe immunodeficiencies, with recurrent infections. Treatments include immunoglobulins, antibiotics, and bone marrow transplantation.
Immunization with oral poliovirus vaccine and yellow fever vaccine are both contraindicated in agammaglobulinemia.